Director of Research and Development
Dr. Yali Su is Director of Research and Development of Kronos Science. She joined KS in March 2004 and is responsible for overseeing, directing, and contributing to all scientific and technical activities. She is also responsible for helping design and refine clinical
studies, directing specialized assay development and testing services for pharmaceutical, biotechnology and clinical research clients.
Prior to joining KS, Dr. Su was an adjunct professor in the Department of Chemistry and Biochemistry at Arizona State University while she worked as a Senior Scientist at Environmental Molecular Science Laboratory in Pacific Northwest National Laboratory (PNNL). She was the principle investigator and program manager for several million dollar projects involving multiple institutions. She has given numerous presentations at national and international scientific meetings and has authored over 50 publications in peer reviewed scientific journals. Dr. Su is an active member of the Society for Free Radical Biology and Medicine and the Women in Science Committee of SFRBM.
Dr. Su attended the University of Notre Dame and received her PhD degree in Physical Chemistry in the Department of Chemistry and Biochemistry. She also holds an MS degree in Radiation Chemistry/Life Science and BS degree in Chemistry from Peking University.
Natalie Lassen, PhD
Research Scientist
Dr. Natalie Lassen currently serves as a Research Scientist at Kronos Scienc. She joined KS in December 2006 and participates in the development of new laboratory assays utilizing esoteric or traditional testing platforms including ELISA, flow cytometry and electrophoresis technologies.
Dr. Lassen has expertise in assessment of cytotoxicity assays, cell culture, enzymology and DNA/protein analysis. Her strengths include her knowledge of analytical techniques for protein purification including FPLC, affinity chromatography, and HPLC.
Prior to joining KS, Dr. Lassen earned her PhD in Molecular Toxicology/Pharmaceutical Sciences at University of Colorado Health Sciences Center where her research was focused on investigating cellular protective mechanisms against oxidative stress induced by UV radiation, DNA damaging agents as well as lipid peroxidation-derived aldehydes. She assessed biological assays to evaluate protein oxidation and aggregation, developed in vitro and in vivo models to investigate hepatic carcinoma and alcohol liver disease and identified new molecular targets for prevention of neurological/ophthalmologic pathologies.
Dr. Lassen received her degree in Molecular Biology from the Department of Experimental Medicine and Oncology, University of Turin, Italy where her studies focused on the identification of prototype molecules involved in the inhibition of proliferation of several hepatoma cell lines. Dr. Lassen’s research has been recognized internationally with meritorious awards, and she will continue her dedication to science at KS.
Susan Yeh, Ph.D.
Research Scientist
Dr. Yeh currently serves as a Research Scientist at Kronos Science. She Joined KS in February 2007 and participates in the development of new laboratory assays utilizing ICP/MS, GFAA, HPLC, LC/MS/MS, and GC/MS/FID technologies.
Dr. Yeh has expertise in organic synthesis and protein characterization using liquid chromatography electrospray ionization quadrupole ion trap (LC-ESI-QIT) [LC/MS/MS], matrix-assisted laser desorption/ionization time-of-flight time-of-flight (MALDI-ToF/ToF), HPLC, NMR, IR, and GC/MS technologies.
Prior to joining Kronos, she was a research scientist in Oregon State University, where she developed protocols of isolation and characterization of the vaccinia virus proteins, and examined myristoylpeptides and myristoylproteins released from vaccinia viruses with HPLC in conjunction with mass spectrometry.
Dr. Yeh received her PhD degree in Organic Chemistry and MS degree in Chemistry from University of California, San Diego. She also holds a BS degree in Chemistry from Fu-Jen Catholic University.
Jane Wang, Ph.D.
Research Scientist
Dr. Wang currently serves as a Research Scientist at Kronos Science. She joined Kronos in January 2009. Dr. Wang has expertise in synthetic organic chemistry, LC/HPLC separation method development, and LC-MS/MS analysis of bioactive small organic molecules and peptides. She is proficient in characterization of organic compounds with analytical instruments such as MNR, MS, UV/Vis, FT-IR. Her synthetic expertise includes molecular synthesis, heterocycle synthesis, solution/solid phase peptide synthesis, solid phase organic synthesis, combinatorial chemistry/parallel synthesis.
Prior to joining Kronos, Dr. Wang was a staff scientist at Sanofi-Aventis Pharmaceuticals, where she synthesized and analyzed by LC-MS, arrays of small organic compounds of pharmacological interest to populate the Sanofi-Aventis screening collection as well as the targeted arrays of organic molecules for SAR studies.
Dr. Wang received her BS in Chemistry from Nankai University in China and PhD in Organic chemistry from Virginia Tech, where she synthesized human Pin1 inhibitors and developed hPin1 inhibition biochemical assays based on enzyme kinetics using UV-Vis. She also worked as a post-doc research associate in Medicinal Chemistry in the Department of Pharmacology and Toxicology at the University of Arizona, where she synthesized and characterized novel heterocyclic compounds as anti-cancer/anti-inflammatory agents targeting protein kinases.