Kronos Science has developed a number of unique assays for its own research projects. Much of this research has focused on aging and longevity, with assays developed to determine oxidative stress, cardiovascular risk, endocrine status and nutritional status. Precise detection is accomplished utilizing liquid chromatography tandem mass spectroscopy (LC/MS/MS), gas chromatography mass spectroscopy (GC/MS), gas chromatography flame ionization detector GC/FID), high performance liquid chromatography (HPLC), inductively coupled plasma mass spectrometry (ICP MS) and atomic absorption analysis. These assays are also available on a contract basis for our clients.
Unique and highly sensitive, these assays for DNA damage, isoprostane analysis, protein peroxidation, high sensitivity vitamins, glutathione, nutritional components, leukotrienes, trace metals, fatty acids and high sensitivity hormones are performed by few laboratories outside of academic centers.
See KS Assays Under Development for upcoming service offerings.
Contact us if you wish to discuss custom assay development
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Category
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Assay
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Methodology
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DNA Damage
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8-hydroxy Guanosine
8-Hydroxy-2-deoxy Guanosine
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LC/MS/MS
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Isoprostanes
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8-iso-Prostaglandin F2α (iPF2α–III)
iPF2α - VI
2,3-dinor-8-iso Prostaglandin F2α
8,12-iso-iPF2α VI
2,3-Dinor iPF1a-III
2,3-Dinor-11ß-Prostaglandin F2α
8-iso-15 (R) Prostaglandin F2a
11ß-Prostaglandin F2α
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LC/MS/MS
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Protein Oxidation
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Chlorotyrosine
Dityrosine
Nitrotyrosine
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LC/MS/MS
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Vitamins
(high sensitivity)
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Vitamin B1 (Thiamine)
Vitamin B2 (Riboflavin)
Vitamin B3 (Niacin)
Vitamin B5 (Pantothenic Acid)
Vitamin B6 (B6a, B6 PLP)
Vitamin B7 (Biotin)
Vitamin C (Ascorbate)
Vitamin D2/D3
Vitamin E
Alpha tocopherol
Delta tocopherol
Gamma tocopherol
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LC/MS/MS
HPLC
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Glutathione
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Glutathione, Reduced (GSH)
Glutathione, Oxidized (GSSG)
Glutathione Total
GSH:GSSG ratio
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LC/MS/MS
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Nutritionals
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Alpha Carotene
Beta Carotene
Beta Cryptoxanthin
Carotenoid Panel
Coenzyme Q10
Lutein
Lycopene
Retinol
Retinyl Palmitate
Zeaxanthin
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HPLC
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| Leukotrienes |
Leukotriene E4 (LTE4)
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LC/MS/MS
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| Hormones |
Leptin
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LC/MS/MS
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